Natural Viagra
https://eddrugs2017.com/natural-alternatives-viagra/ 

Natural Viagra became the first effective and safe peroral preparation for erectile dysfunction (ED) treatment. The relation of medicine to this disease underwent cardinal changes within the last hundred years. Now does not raise doubts that the disturbances of an erection surveyed earlier as a consequence of psychological problems, in most cases are implication of the organic lesion which quite often have systemic character [1]. The main stages of development of sex medicine in the XX century are presented in table 1. The history of discovery of Natural Viagra is an example of how casual observation can have huge impact on a course of scientific progress. In the course of clinical tests of a new anti-anginal preparation researchers of Pfizer Inc. noticed that though drug intake is not accompanied by significant clinical improvement of a course of stenocardia, at many patients it leads to development of the peculiar "side effect" consisting in improvement of erectile function [2]. This observation became the reason of studying of possibility of application of this substance in ED treatment.
However, it is not necessary to think that discovery of Natural Viagra was simple good luck. It was preceded by accumulation of knowledge of a role of oxide of NO nitrogen in providing a normal functional state of cardiovascular system, the foundation to which laid Furchgott and Zawadski [3]. The authors who have got further for the opening the Nobel Prize, found out that in the presence of an intact endothelium influence of Acetylcholinum leads to a dozozavisimy relaxation of the isolated segment of arteries as a result of influence of an endothelial relaksiruyushchy factor. Further researches showed that this factor is NO synthesized from a L-arginine by enzyme NO синтазой (NOC) [4].

Natural Viagra
https://eddrugs2017.com/natural-alternatives-viagra/ 

Being allocated from endothelial cells of NO diffuses in a subject gladkomyshechny tissue where enzyme гуанилатциклаза therefore the quantity sharply increases in cells cyclic a guanosine of mononatrii phosphas (CGMP) is activated that, in turn conducts to depression of intracellular concentration of ions of a calcium and a relaxation. The destruction of the CGMP limiting vazorelaksiruyushchy effect of NO, is carried out by enzyme фосфодиэстераза (FDE). Now 11 types of this enzyme are known, thus in CGMP destruction in the gladkomyshechnykh cells of vessels the main role is played by FDE 1,3 and 5 of types [5]. Thus, oppression of FDE leads to intensifying of effects of oxide of nitrogen.

Natural Viagra
https://eddrugs2017.com/natural-alternatives-viagra/ 

The erection of a penis is the hemodynamic phenomenon which first stage is the relaxation the gladkomyshechnykh of cells of cavernous arteries and the trabeculas, bringing to filling with a blood of cavernous ph. The relaxation of a gladkomyshechny tissue of the last, as well as in other vascular systems, is provided with action of NO which is allocating from an endothelium and not cholinergic not adrenergic nervous terminations [6]. Discovery of Natural Viagra, a selective inhibitor (FDE-5) FDE 5, became the reason of the numerous basic researches which have shown what exactly this type of enzyme dominates in a cavernous tissue that provides selectivity of influence of a preparation [7]. It is necessary to notice that these researches allowed to find out also mechanisms of action and others, already long time of preparations applied in clinical practice, in particular, a papaverine and E1 [8] prostaglandin, and considerably to dilate knowledge of the mechanism of an erection and its disturbances leading to ED.
Emergence of Natural Viagra had a great impact and on clinical trials in the field of sex medicine. In recent years terminology was specified and new definitions of different forms of sex disturbances are developed. Clinical tests of Natural Viagra became incentive for creation of new diaries and questionnaires for an assessment of a condition of sex function of men. The analysis of demographic indicators of participants of large-scale clinical tests allowed to tap risk factors of ED that, in turn, promoted comprehension of its pathogenesis [9].
Emergence of Natural Viagra had a huge public response. A large number of the sick ED which earlier were not addressing to doctors, received hope for treatment, and so far million men around the world returned to normal sex life thanks to reception of this preparation.